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Double Your Impact

A generous couple is matching all gifts, dollar-for-dollar, up to $100,000.

A generous couple is matching all gifts, dollar-for-dollar, up to $100,000.
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Southern California Region

The American Red Cross Southern California Region serves San Diego, Orange, Riverside, San Bernardino, Imperial, Inyo, and Mono Counties. We provide food and shelter in emergencies, assist military members and their families, teach lifesaving skills, ensure we maintain a safe and stable blood supply, and so much more. 

Local Events

Annual Real Heroes Awards
24th Annual Real Heroes Awards

Friday, October 2, 2026

7:30 a.m. - 9:00 a.m. PDT

USS Midway Museum, San Diego

The 24th Annual Real Heroes Awards is a celebration honoring local heroes for courage, compassion and leadership!

Orange County Heroes Awards banner.
Orange County Heroes Awards

May 13, 2027

The Richard Nixon Presidential Library

Join us as we meet incredible heroes!

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Get Involved

Red Cross volunteer installing smoke alarm in house.
Become a Volunteer
Your time and talent can make a difference in the lives of others.
Learn More
Man sitting in a chair giving blood and speaking with a phlebotomist.
Students in a Red Cross CPR class practicing on a mannequin.
Expert Training That Fits Your Schedule
Get Trained & Certified
Take a Class
Red Cross volunteer speaking with man in room full of cots.
You Can Make a Difference
Help people affected by disasters big and small with a financial gift.
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Our Locations

Red Cross volunteer holding a Red Cross blanket and standing in a shelter surrounded by shelter cots.
The American Red Cross Southern California Region serves San Diego, Orange, Riverside, San Bernardino, and Imperial Counties.
Find the local chapter near you

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List of blood locations

San Diego Region HQ
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3950 Calle Fortunada
San Diego, CA 92123
(858) 309-1200 Details
Orange County
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600 Parkcenter Dr.
Santa Ana, CA 92705
(714) 481-5300 Details
Riverside County
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6235 River Crest Drive, Suite A
Riverside, CA 92507
(888) 831-0031 Details
Palm Desert/Coachella Valley
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72559 CA-Highway 111
Palm Desert, CA 92260
(888) 831-0031 Details
Imperial County
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703 Industry Way, Suite 3
El Centro, CA 92243
(760) 352-4541 Details
San Bernardino County
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10600 Trademark Parkway, Suite 406
Rancho Cucamonga, CA 91730
(909) 888-1481 Details
Victorville/High Desert
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17199 Yuma Street, Suite 2
Victorville, CA 92395
(442) 286-0079 Details
American Red Cross - Twentynine Palms
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Family Service Center, Building 693, Suite 107
Twentynine Palms, CA 92278
(760) 830-6685 Details
American Red Cross - Fort Irwin
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1204 Normandy Dr.
Fort Irwin, CA 92310
(760) 380-3697 Details

Blood Donation Centers

The need for blood is constant and your contribution is important for a healthy and reliable blood supply. You will feel good knowing you've helped change a life. Schedule an appointment at one of our locations.

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Blood Location Centers

Laguna Hills Red Cross Blood, Platelet and Plasma Donation Center
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22971 Mill Creek Dr
Laguna Hills, CA 92653
1-800-RED CROSS Details
Santa Ana Red Cross Blood, Platelet and Plasma Donation Center
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600 Park Center Drive
Santa Ana, CA 92705
1-800-RED CROSS Details
Fountain Valley Red Cross Blood Donation Center
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17800 Newhope St
Fountain Valley, CA 92708
1-800-RED CROSS Details
Fullerton Red Cross Blood, Platelet and Plasma Donation Centers
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1379 S Harbor Blvd
Fullerton, CA 92832
1-800-RED CROSS Details
Kearny Mesa Red Cross Blood, Platelet and Plasma Donation Center
Get Directions
4229 Ponderosa Ave, Suite C
San Diego, CA 92123
1-800-RED CROSS Details
Riverside American Red Cross Blood and Platelet Donation Center

Get Directions
6235 River Crest Dr., Ste. A
Riverside, CA 92507
1-800-RED CROSS Details

News

A man sits across from a woman sitting on bed covered with Red Cross blankets.
Red Cross Helping as Illinois, Indiana Weather Non-stop Storms
August 19, 2026
A group of five people in Red Cross clothing on stand in a row with their backs to the camera and their arms wrapped around each other’s shoulders. A rural medical building can be seen in the background.
World Humanitarian Day: One Life Lost Is Far Too Many
August 19, 2026
Red Cross volunteers and World Central Kitchen team members stand together with meal supplies and a World Central Kitchen food truck in the background.
Red Cross Volunteers Provide Vital Community Support During Orange County Hazardous Materials Incident
By Brianna Kelly, American Red Cross
July 30, 2026
Child in the grocery story produce section holding up a small card that says WIC on the front
Volunteer Spotlight: Supporting the Red Cross Women, Infants and Children Program
By Romina Gomez Silva, American Red Cross
July 30, 2026
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