In 1905, William Howard Taft, then Secretary of War under President Theodore Roosevelt, appealed to community leaders in his hometown of Cincinnati to organize an American Red Cross Chapter. In 1910, the local Red Cross began to take on new functions, opening its first classes in home care of the sick, first aid, elementary hygiene and dietetics.
In 1938 the Chapter established a blood donor service for servicemen with Dr. Paul I. Hoxworth as head of operations. Following World War II, the Blood Donor Center was closed. During its years of operation, the Center collected 335,000 pints of blood from 85,000 people. Currently, with the increase in for-profit blood banks, only a few counties in the Ohio River Valley continue to offer Red Cross blood services.